报告题目：Reactivation of an Oncofetal Protein in Cancer

报告人：Dr. Daniel G Tenen
　　　　Director, Cancer Science Institute of Singapore
　　　　Distinguished Professor, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore
　　　　Professor of Medicine, Harvard Medical School
　　　　Director, Blood Program, Harvard Stem Cell Institute

报告时间：2015年9月24日上午9：30

报告地点：金沙8888js官方一楼中厅

Over the past 30 years, Dr. Tenen's laboratory has made seminal contributions to understanding the role of transcriptional regulation in cell differentiation and the role of disruption of these pathways in leukemia, lung cancer, and liver cancer. These efforts have included basic studies understanding gene regulation in normal and leukemic hematopoietic stem cells, leading to development of novel ways of manipulating gene expression in stem cells as well as exploiting differences between normal and leukemic stem cells as a basis for targeted leukemia stem cell therapy, and the role of stem cell oncofetal proteins in leukemia and solid tumors, especially liver cancer. His recent studies have focused on noncoding RNAs, and include published findings on antisense RNAs, RNA editing, and noncoding RNAs in gene regulation, methylation, and cancer. His most recent studies demonstrated that RNA can regulate DNA methylation, and that RNA can be utilized to induce demethylation in a gene-specific manner.