Position Title: Post-doctoral Fellow and/or Research Associate

Number of Vacancies: 2

School/College/Division/Institutes/Centers

06 - School of Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA Primary Department: Ophthalmology, Visual and Anatomical Sciences

Essential Functions (Job Duties)

Under the direction of a senior investigator, designs, executes, analyzes, and interprets various laboratory experiments with a focus on current scientific questions in the field of diabetic wound healing and nerve de/regeneration, as identified by the senior scientists.

Unique Duties

Postdoctoral position in vision research is available in Prof. Fu-Shin Yu’s laboratory, Wayne State University School of Medicine, to carry out an interdisciplinary project to study the mechanisms underlying defects in wound healing and sensory nerve regeneration using mouse models of human type 1 and 2 Diabetes. We are seeking for a highly motivated postdoctoral fellow with experience in molecular and cell biology, and interested in vision research. The research will be focused on evaluation of exosome cargo contents and function, and of their defects in diabetic cells and tissues. This position requires the expertise in cell biology and molecular biology techniques, including PCR, qRT-PCR, Western Blotting, flow cytometry, fluorescence microscopy, immunostaining. Prior work experience with small animal surgery would be desired. Successful candidate will be a part of an interdisciplinary team focused on development and pre-clinical evaluation of biologics in treating delayed diabetic wound healing.

Qualifications

Applicant must have PhD and/or MD in biology or related field. The ability to conduct independent scientific investigations is required.

Preferred Qualifications: Small animal surgeryskill. Job Type: Full Time

Salary range$36,000-$47,000 plus full fringe benefit.

Requirements:Applicant must have PhD and/or MD in biology or related field. The ability to conduct independent scientific investigations is required.

How to apply: Please submit cover letter, CV, and contact information for 2-3 references in one pdf file by e-mail to:fyu@wayne.edu.Contact: Fu-Shin X. Yu, Ph.D. Kresge Eye Institute, Department of Ophthalmology, Visual and Anatomical Sciences,Wayne State University School of Medicine 4717 St. Antoine, Room K417, Detroit, MI 48201

Relevant publications:

1) Gao N, Yan C, Lee P, Sun H, and Yu FS. Dendritic cell dysfunction and diabetic sensory neuropathy in the cornea.J Clin Invest.2016;126(5):1998-2011.

2) Lee PS, Gao N, Dike M, Shkilnyy O, Me R, Zhang Y, and Yu FX. Opposing Effects of Neuropilin-1 and -2 on Sensory Nerve Regeneration in Wounded Corneas: Role of Sema3C in Ameliorating Diabetic Neurotrophic Keratopathy.Diabetes.2019;68(4):807-18.

3) Sun H, Lee P, Yan C, Gao N, Wang J, Fan X, and Yu FS. Inhibition of Soluble Epoxide Hydrolase 2 Ameliorates Diabetic Keratopathy and Impaired Wound Healing in Mouse Corneas.Diabetes.2018;67(6):1162-72.

4) Bettahi I, Sun H, Gao N, Wang F, Mi X, Chen W, Liu Z, and Yu FS. Genome-wide transcriptional analysis of differentially expressed genes in diabetic, healing corneal epithelial cells: hyperglycemia-suppressed TGFbeta3 expression contributes to the delay of epithelial wound healing in diabetic corneas.Diabetes.2014;63(715-27.

5) Gao N, Lee P, and Yu F-S. Intraepithelial dendritic cells and sensory nerves are structurally