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Post-doc Position(2016-10-18)
AA postdoctoral position is available in Dr. Erfei Bi laboratory to conduct research on the septin cytoskeleton, an exciting area of cell biology. Septins are conserved from yeast to human. They form distinct higher‑order structures to perform diverse functions including cytokinesis, cell morphogenesis, and cell migration. Mutations or overexpression of septins are associated with serious diseases such as neurodegenerative diseases, cancer, and infertility. We seek a highly motivated postdoctoral fellow to study the architecture, dynamics, and function of the septin cytoskeleton in the budding yeastSaccharomyces cerevisiaewhere this family of proteins was first identified. The proposed study will be carried out using cutting‑edge technologies including platinum replica electron microscopy (in collaboration with Dr. Tatyana Svitkina who pioneered this technique) and various advanced fluorescence light microscopy. Candidates with a Ph.D. in biological science, especially those with expertise in fungal genetics, live cell imaging, and biochemistry, are encouraged to apply. The postdoc will work with a vibrant group of people studying cell polarization and cytokinesis in yeast. The position is renewable for up to four years.
To apply, please send your CV, a short summary of your current research, and two letters of recommendation to Dr. Erfei Bi (ebi@mail.med.upenn.edu; Tel: 215-573-6676), Professor of Cell and Developmental Biology in the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104-6058. You can also learn more about our research program from the following papers:
1. Oh, Y., and E. Bi. 2011. Septin structure and function in yeast and beyond.Trends Cell Biol.21:141-148.
2. Wloka, C., E.A. Vallen, L. Thé, X. Fang, and E. Bi. 2013. Immobile myosin‑II plays a scaffolding role during cytokinesis in budding yeast.J. Cell Biol.200:271‑286. (Highlighted in Biosights with a podcast entitled“Erecting a scaffold for cytokinesis”).
3. Okada, S., M. Leda, J. Hanna, N.S. Savage, E. Bi*, and A. Goryachev*. 2013. Daughter cell identity emerges from the interplay of Cdc42, septins, and exocytosis.Dev. Cell: 26:148-161 (Cover story for the July 28th2013 issue, with a commentary entitled"Bud building by septin patch hole punching") (*co‑corresponding author).
4. Wang T, Yanger K, Stanger BZ, Cassio D, Bi E. 2014. Cytokinesis defines a spatial landmark for hepatocyte polarization and apical lumen formation.J. Cell Sci. 127:2483‑92 (Highlighted in “In this issue” with a piece entitled “Cytokinesis links polarization and tube formation in liver”).
5. Ong K, Wloka C, Okada S, Svitkina T*, Bi E*. 2014. Architecture and dynamic remodeling of the septin cytoskeleton during the cell cycle. Nature Communications.Dec 5;5:5698. doi: 10.1038/ncomms6698 (*co‑corresponding author).
6. Ong K, Svitkina T*, Bi E*. 2016. Visualization of in vivo septin ultrastructures by platinum replica electron microscopy.Methods Cell Biol.136:73-97 (Cover image) (*co‑corresponding author).
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