该信息由2005级博士胡业勤提供。

类似于德国的中科院，马普所的前身是德国的威廉皇帝研究院2006年由泰晤士报高等教育增刊的非大学类研究所的排名中，马普所名列第一位，技术研究专项排名第三（第一和第二是美国的AT&T公司和美国阿贡国家实验室

Max-Planck-Institute of Immunobiology and Epigenetics,

Freiburg, Germany

Ph.D. studentposition available

The research group led by Dr. Jianying YANG and Prof. Dr. Michael Reth in the Max Planck Institute of Immunobiology and Epigenetics (MPI-IE),is looking foran enthusiasticcandidate to fill one graduate student position to join the research on “Structure and signaling ofB cell receptor (BCR)”. Recently,we have discoveredthe auto-inhibitory oligomers of BCR on the surface of resting B cells, and proposed a novel BCR activation model (ref. 1-2). Our current focus is how the surface organization of BCR regulates its function. The candidate is expected to combine molecular signaling studies with modern living cell imaging technologies, including super-resolution microscopy and fluorescence correlation spectroscopy, forelucidating the kinetics of BCR oligomers formation, the structural changes of BCR oligomers upon antigen or antibody simulation, and the interaction of BCR with its co-receptors, in order to achieve a profound understanding of BCR activation mechanism.

As one of the top biomedical research center in Europe, MPI-IEoffers a highly competitive and international research environment to pursue doctoral studies. Our group is associated toCentre for Biological Signalling Studies (BIOSS), University of Freiburg, which is one of the recently established “German Cluster of Excellence” focusing on analytical and synthetic approaches in biological signaling research.

The applicant must hold a master degree. Research background in immunology and molecular biology is preferred. Excellent English skills are required. Knowledge of German language is not obligatory.

To apply, please send curriculum vitae, a motivation letter, and the names and addresses of three referees to:

Dr. Jianying YANG or Prof. Dr. Michael Reth

Department of Molecular Immunology

Max-Planck-Institute of Immunobiology and Epigenetics

Stübeweg 51

79108 Freiburg

Germany

email: Jianying YANG< yang@immunbio.mpg.de>;

or Michael Reth

Selected references:

1. Yang, J. &Reth, M. Oligomeric organization of the B-cell antigen receptor on resting cells.Nature467,465–469 (2010).

2. Yang, J. &Reth, M. The dissociation activation model of B cell antigen receptor triggering.FEBS Lett584,4872–4877 (2010).