学 历
学士. 1983，武汉大学生物系
硕士. 1986，武汉大学生物系
博士. 1991, 美国内华达大学生物化学系
博士后， 1993－1995，美国弗吉利亚大学
博士后， 1995－1998，美国华盛顿大学
主要工作经历与任职
1998-2005.7， Immunex公司/Amgen公司，美国西雅图，历任初级科学家、科学家、高级科学家
2005.8.– 金沙8888js官方教授
目前主要研究领域和兴趣
本实验室以蛋白质组学及生物质谱学为主要研究方法，重点研究感染与天然免疫过程中的蛋白组变化以及蛋白质信号传导通路。
教学情况
每年秋季，本科生生物化学必修课（弘毅班与国际班），研究生蛋白质组学课程；
每年春季，本科生蛋白质组学选修课。
代表性论文
Zhou, M. T., Y. Qin, M. Li, C. Chen, X. Chen, H. B. Shu and L. Guo (2015). "Quantitative Proteomics Reveals the Roles of Peroxisome-associated Proteins in Antiviral Innate Immune Responses."Mol Cell Proteomics14(9): 2535-49.
Li, H. Y., L. K. Zhang, X. J. Zhu, J. Shang, X. Chen, Y. Zhu and L. Guo (2015). "Analysis of EV71 infection progression using triple-SILAC-based proteomics approach."Proteomics15(21): 3629-43.
Zeng, H. L., X. Rao, L. K. Zhang, X. Zhao, W. P. Zhang, J. Wang, F. Xu and L. Guo (2014). "Quantitative proteomics reveals olfactory input-dependent alterations in the mouse olfactory bulb proteome."J Proteomics109C: 125-142.
Zhao, X., S. Sidoli, L. Wang, W. Wang, L. Guo, O. N. Jensen and L. Zheng (2014). "Comparative proteomic analysis of histone post-translational modifications upon ischemia/reperfusion-induced retinal injury."J Proteome Res13(4): 2175-86.
Qin, Y., M. T. Zhou, M. M. Hu, Y. H. Hu, J. Zhang, L. Guo, B. Zhong and H. B. Shu (2014). "RNF26 Temporally Regulates Virus-Triggered Type I Interferon Induction by Two Distinct Mechanisms."PLoS Pathog10(9): e1004358.
Yao, Q., B. Q. Liu, H. Li, D. McGarrigle, B. W. Xing, M. T. Zhou, Z. Wang, J. J. Zhang, X. Y. Huang and L. Guo (2014). "C-terminal Src kinase (Csk)-mediated phosphorylation of eukaryotic elongation factor 2 (eEF2) promotes proteolytic cleavage and nuclear translocation of eEF2."J Biol Chem289(18): 12666-78.
Tian, H., L. Wang, R. Cai, L. Zheng and L. Guo (2014). "Identification of protein network alterations upon retinal ischemia-reperfusion injury by quantitative proteomics using a Rattus norvegicus model."PLoS One9(12): e116453.
Yan, J., H. Tian, S. Wang, J. Shao, Y. Zheng, H. Zhang, L. Guo and Y. Ding (2014). "Pollen developmental defects in ZD-CMS rice line explored by cytological, molecular and proteomic approaches."J Proteomics108C: 110-123.
Zhang, L. K., F. Chai, H. Y. Li, G. Xiao and L. Guo (2013). "Identification of host proteins involved in Japanese encephalitis virus infection by quantitative proteomics analysis."J Proteome Res12(6): 2666-78.
Hou, D., L. Zhang, F. Deng, W. Fang, R. Wang, X. Liu, L. Guo, S. Rayner, X. Chen, H. Wang and Z. Hu (2013). "Comparative Proteomics Reveal Fundamental Structural and Functional Differences between the Two Progeny Phenotypes of a Baculovirus."J Virol87: 829-839.
Chen, X., Y. Zhao, G.-M. Li and L. Guo (2013). "Proteomic analysis of mismatch repair-mediated alkylating agent-induced DNA damage response."Cell & Biosciences3: 37.
Liu, G., H. Tian, Y. Q. Huang, J. Hu, Y. X. Ji, S. Q. Li, Y. Q. Feng, L. Guo and Y. G. Zhu (2012). "Alterations of Mitochondrial Protein Assembly and Jasmonic Acid Biosynthesis Pathway in Honglian (HL)-type Cytoplasmic Male Sterility Rice."J Biol Chem287(47): 40051-60.
Chen, C., D. Wu, L. Zhang, Y. Zhao and L. Guo (2012). "Comparative phosphoproteomics studies of macrophage response to bacterial virulence effectors."J Proteomics77: 251-61.
Xu, H., W. Zhang, Y. Gao, Y. Zhao, L. Guo and J. Wang (2012). "Proteomic analysis of embryo development in rice (Oryza sativa)."Planta235(4): 687-701.
Yao, Q., H. Li, B. Q. Liu, X. Y. Huang and L. Guo (2011). "SUMOylation-regulated Protein Phosphorylation, Evidence from Quantitative Phosphoproteomics Analyses."J Biol Chem286(31): 27342-9.
Yu, J. L. and L. Guo (2011). "Quantitative proteomic analysis of Salmonella enterica serovar Typhimurium under PhoP/PhoQ activation conditions."J Proteome Res10(7): 2992-3002.
Ma, Y., Y. Zhao, R. Zhao, W. Zhang, Y. He, Y. Wu, Z. Cao, L. Guo and W. Li (2010). "Molecular diversity of toxic components from the scorpion Heterometrus petersii venom revealed by proteomic and transcriptome analysis."Proteomics10(13): 2471-85.
Wang, R., F. Deng, D. Hou, Y. Zhao, L. Guo, H. Wang and Z. Hu (2010). "Proteomics of the Autographa californica nucleopolyhedrovirus budded virions."J Virol84(14): 7233-42.
Zhou, Z., J. B. Fan, H. L. Zhu, F. Shewmaker, X. Yan, X. Chen, J. Chen, G. F. Xiao, L. Guo and Y. Liang (2009). "Crowded cell-like environment accelerates the nucleation step of amyloidogenic protein misfolding."J Biol Chem284(44): 30148-58.
Deng, F., R. Wang, M. Fang, Y. Jiang, X. Xu, H. Wang, X. Chen, B. M. Arif, L. Guo and Z. Hu (2007). "Proteomics analysis of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus identified two new occlusion-derived virus-associated proteins, HA44 and HA100."J Virol81(17): 9377-85.
