学习经历

2002 - 2007 博士 中国科学院生物物理研究所生物大分子国家重点实验室

导师：王大成院士

1998 - 2002 学士 金沙8888js官方基地班专业

主要工作经历与任职情况：

2014 - 至今 教授 金沙8888js官方病毒学国家重点实验室

2008 - 2013 研究助理 美国霍华德休斯医学研究所（HHMI）

导师：John Kappler 院士

Philippa Marrack 院士 英国皇家学会会员

研究方向

病原识别及精准免疫治疗与基因编辑

主要研究领域及兴趣

病原识别是免疫应答中的极其重要的事件，其识别的有效性影响疾病防治，识别的精准性又关乎脱靶等副作用。在人体内若T细胞受体有效识别外源抗原和MHC的复合物则能产生免疫保护作用，若脱靶异常识别自身抗原和MHC的复合物则又可造成机体组织的免疫损害，直接影响感染性疾病的免疫防治、自身免疫防治和组织移植免疫排斥等。细菌内负责外源病毒核酸识别的免疫防御蛋白 CRISPR-Cas如高效精准识别靶标DNA则能有助于疾病防治，若错误识别非靶标DNA则会产生严重脱靶副作用。这些病原精准识别在科学意义和疾病防治的重要性已在肿瘤免疫疗法和基因编辑等研究上不断凸显。

我们沿着病原识别及其阻断和强化为主线，综合病原确定、结构特征和分子识别分析、免疫信息研究、细胞与小鼠模型功能验证和临床相关性检验，开展对应的基因编辑和肿瘤免疫防治的综合研究并进行医药设计开发。获批并评审973课题，国家自然科学基金等多个项目。以责任作者在《Immunity》、《Genome Biology》、《Science Advances》、《Immunological Reviews》、《PNAS》、《Molecular Therapy》和《JID》等一区杂志上发表多篇研究成果，两篇入选科学论文专业高评系统 Faculty of 1000，两篇配发特邀评论文章重点介绍，一篇入选杂志封面，一篇入选ESI高被引论文，已开发出多个药物分子，并获批发明专利5项。

论文简要列表

1.Liu Y, Lei J, San D, Yang Y, Paek C, Xia Z, Chen Y*,Yin L*. Structural basis for unusual TCR CDR3β usage against an immunodominant HIV-1 Gag protein peptide restricted to an HLA-B*81:01 molecule. Front. Immunol. 31 January 2022; doi.org/10.3389/ fimmu.2022.822210.（二区）

2.Zhou J, Chen P, Wang H, Liu H, Li Y, Zhang Y, Wu Y, Paek C, Sun Z, Lei J,Yin L*.Cas12a variants designed for lower genome-wide off-target effect through stringent PAM recognition.Molucular Therapy2021 10.1016/j.ymthe.2021.10.010.（一区）Yang Y,

3. Wei P, Jordan K, Buhrman J, Lei J, Deng H, Marrack P, Dai S, Kappler JW*, Slansky J*,Yin L*. Structures suggest an approach for converting weak self-peptide tumor antigens into superagonists for CD8 T cell in cancer.PNAS2021 Jun 8;118(23) (一区)

4.Chen P, Zhou J, Wan Y, Liu H, Li Y, Liu Z, Wang H, Lei J, Zhao K, Zhang Y, Wang Y, Zhang X,Yin L*. A Cas12a ortholog with stringent PAM recognition followed by low off-target editing rates for genome editing.Genome Biology.2020 Mar 25;21(1):78. (一区)

5.Qu Z, Zhou J, Zhou Y, Xie Y, Jiang Y, Wu J, Luo Z, Liu G,Yin L*, Zhang XL*. Mycobacterial EST12 activates a RACK1-NLRP3-gasdermin D pyroptosis immune pathway.Science Advances.2020 Oct 23;6(43) (一区)

6. Bai P, Zhou Q, Wei P, Bai H, Chan SK, Kappler JW, Marrack P,Yin L*. Rational discovery of a cancer neoepitope harboring the KRAS G12D driver mutation.Sci China Life Sci.2021 Mar 16. doi: 10.1007/s11427-020-1888-1（一区）

7.Yang Y，Bai H, Wu Y, Chen P, Zhou J, Lei J, Ye X, Brown A, Zhou X, Shu T, Chen Y, Wei P*,Yin L*.The Activating receptor KIR2DS2 bound to HLA-C1 reveals the novel recognition features of activating receptor.Immunology2021 Dec 30. doi: 10.1111（二区）

8. Liu Y, Wu Y, Liu B, Zhang Y, San D, Chen Y, Zhou Y, Yu L, Zeng H, Zhou Y, Zhou F, Yang H,Yin L*, Huang Y*. Biomarkers and Immune Repertoire Metrics Identified by Peripheral Blood Transcriptomic Sequencing Reveal the Pathogenesis of COVID-19.

Front Immunol.2021 Aug 24;12:677025（二区）

9.Bai P*, Li Y, Zhou Q, Xia J, Wei PC, Deng H, Wu M, Chan SK, Kappler JW, Zhou Y, Tran E, Marrack P,Yin L*.Immune-based mutation classification enables neoantigen prioritization and immune feature discovery in cancer immunotherapy.Oncoimmunology.2021 Jan 15;10(1)（二区）

10.Xia J, Bai P, FanW, Li Q, Li Y, Wang D,Yin L*and Zhou Y* NEPdb: A Database of T-Cell Experimentally-Validated Neoantigens and Pan-Cancer Predicted Neoepitopes for Cancer Immunotherapy.Front. Immunol.2021 Apr 13;12:644637. doi: 10.3389（二区）

11. Lei J, Wang HJ, Zhu DM, Wan YB,Yin L*.Combined effects of avasimibe immunotherapy, doxorubicin chemotherapy and Metal-Organic Frameworks nano-particles on breast cancer.Journal of Cellular Physiology. 2019 DOI: 10.1002/jcp.29358 （二区）

12. Wei P, Song G, Shi M, Zhou Y, Liu Y, Lei J, Chen P,Yin L*.Substrate analog interaction with MCR-1 offers insight into the rising threat of the plasmid-mediated transferable colistin resistance.FASEB J.2018 Feb; 32(2):1085-1098 (Cover Story， ESI highly cited) （二区）

13.Wei P, Yang Y, Liu Z, Luo Z, Tu W, Han J, Deng Y,Yin L*.Characterization of Autoantigen Presentation by HLA-C*06:02 in Psoriasis.J Invest Dermatol.2017 Oct; 137(10):2238-2241 (Highlighted by Commentary in J Invest Dermatol. 2017 Oct; 137:2042-2045) （一区）

14.Shu T, Gan T, Bai P, Wang X, Qian Q, Zhou H, Cheng Q, Qiu Y, Yin L, Zhong J, Zhou X. Ebola virus VP35 has novel NTPase and helicase-like activities.Nucleic Acids Res.2019 Jun 20;47(11):5837-5851. （一区）

15.Ju LG, Zhu Y, Long QY, Li XJ, Lin X, Tang SB, Yin L, Xiao Y, Wang XH, Li L, Zhang L, Wu M. SPOP suppresses prostate cancer through regulation of CYCLIN E1 stability.Cell Death Differ.2019 Jun;26(6):1156-1168. （一区）

16.Sun MS, Zhang J, Jiang LQ, Pan YX, Tan JY, Yu F, Guo L, Yin L, Shen C, Shu HB, Liu Y. TMED2 Potentiates Cellular IFN Responses to DNA Viruses by Reinforcing MITA Dimerization and Facilitating Its Trafficking.Cell Rep.2018 Dec 11;25(11):3086-3098. （一区）

17.Zhao Y, Wang X, Wang Q, Deng Y, Li K, Zhang M, Zhang Q, Zhou J, Wang HY, Bai P, Ren Y, Zhang N, Li W, Cheng Y, Xiao W, Du HN, Cheng X, Yin L, Fu X, Lin D, Zhou Q, Zhong B. USP2a Supports Metastasis by Tuning TGF-β Signaling.Cell Rep.2018 Feb 27;22(9):2442-2454. （一区）

18.Zhang S, Cheng Q, Luo C, Yin L, Qin Y, Chen M. An alanine residue in human parainfluenza virus type 3 phosphoprotein is critical for restricting excessive N0-P interaction and maintaining N solubility.Virology.2018 May;518:64-76. （二区）

19.Xiao X, Tang JJ, Peng C, Wang Y, Fu L, Qiu ZP, Xiong Y, Yang LF, Cui HW, He XL,Yin L, Qi W, Wong CL, Zhao Y, Li BL, Qiu WW*, Song BL*. Cholesterol modification of Smoothened is required for hedgehog signaling.Molecular Cell.2017; 66:1-9 （一区）

20.Hu MM, Yang Q, Xie XQ, Liao CY, Lin H, Liu TT, Yin L, Shu HB*. Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus.Immunity.2016 Sep 20; 45(3):555-69. （一区）

21.Xia H, Wang P, Wang GC, Yang J, Sun X, Wu W, Qiu Y, Shu T, Zhao X, Yin L, Qin CF, Hu Y, Zhou X*. Human Enterovirus Nonstructural Protein 2CATPase Functions as Both an RNA Helicase and ATP-independent RNA Chaperone.PLOS Pathogens.2015; 11(7): e1005067. doi: 10.1371/journal.ppat.1005067 （一区）

22.Yang J, Cheng Z, Zhang S, Xiong W, Xia H, Qiu Y, Wang Z, Wu F, Qin CF, Yin L, Hu Y and Zhou X*. A Cypovirus VP5 Displays the RNA Chaperone-like Activity that Destabilizes RNA Helices and Accelerates Stranding Annealing.Nucleic Acids Research.2014; 42(4): 2538-2554. （一区）

23.Yin L*, Dai S, Clayton G, Gao W, Wang Y, Kappler J, Marrack P*. Recognition of self and altered self by T cells in autoimmunity and allergy.Protein & cell2013 Jan; 4(1):8-16 (* Corresponding) （一区）

24.Yin L, Crawford F, Marrack P, Kappler J*, Dai S*. T-cell receptor(TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy.PNAS（Proceedings of the National Academy of Sciences）2012 Nov 6; 109(45):18517-22 (Recommended by Faculty of 1000) （一区）

25.Yin L, Scott-Browne J, Kappler J, Gapin L, Marrack P*. T cells and their eons-old obsession with MHC.Immunological Reviews.2012 Nov; 250(1):49-60. （一区）

26.Yin L#, Huseby E#, Scott-Browne J, Rubtsova K, Pinilla C, Crawford F, Marrack P, Dai S, Kappler J*. A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers.Immunity.2011 Jul 22; 35(1):23-33(# Contributed equally)

(Highlighted by Commentary in Immunity 2011 Jul 22; 35:1-3, Recommended by Faculty of 1000) （一区）

编辑书籍

1. 殷雷 “第29章：免疫信息学研究进展”，《免疫学及实验技术新进展》，2018，中华医学电子音像出版社

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