教育经历
1979-1983 华中农业大学,畜牧兽医学专业本科生
1983-1986 四川农业大学,动物遗传育种学专业硕士生
1990-1993 华西医科大学,生物化学与分子生物学专业博士生
主要工作经历与任职情况
1986-1990 华中农业大学,助教
1993-至今 武汉大学,讲师、副教授、教授、博士生导师
主要社会兼职
2008-2009年度教育部科技奖励评审专家;
2014年-现在 湖北省细胞生物学学会理事、教学与科普专业委员会主任
2013年-现在 国家精品课程《生物化学》资源共享升级负责人
2000年-2012年 全国高考阅卷生物科目负责人(湖北省)
主要科研奖励和个人荣誉
1998年武汉大学首届珞珈青年赤子优秀奖;
2002年四川省科技进步奖一等奖(第六);
2005湖北省自然科学二等奖(第二);
2005年获批教育部新世纪人才计划;
2006年入选年度中国青年科技协会会员;
2005-2007年度武汉大学优秀女教工荣誉;
2008年武汉市三八红旗手称号;
2009年湖北省先进女教职工荣誉称号;
先后获得有武汉大学教学成果奖二等奖、本科生教学优秀质量奖、年度优秀导师奖;金沙8888js官方本科生优秀导师奖、本科生优秀教学奖和教职工年度优秀评级。
承担课程
本科生:1.生物化学 2.细胞生物学实验课
研究生:动物分子细胞生物学
主持课题项目
国家自然科学基金面上项目多项
留学回国基金
湖北省自然科学基金
教育部新世纪优秀人才培养计划基金项目
国家级精品资源共享课立项
973重大研究计划子项目(*)
*注明参加项目
主要研究领域和兴趣
我们的研究领域是动物及人类分子细胞生物学。通过人类及多模式物种(主要是小鼠,斑马鱼和黄鳝)研究早期胚胎发育、分化和器官形成过程中所涉及的众多基因的时空表达与调控;研究基因-发育-进化等生命本质, 尤其关注生殖与发育、细胞分化、干细胞命运及小RNA等生命活动及其分子病理机制。
发表的论文(#并列第一作者,*通讯作者)
1. Cheng H.*, Shang D. and Zhou R.*, Germline stem cells in human, Signal Transduct. Target. Ther. 2022,7(1):345.
2. Cheng H.* and Zhou R.*, Decoding genome recombination and sex reversal. Trends in Endocrinology & Metabolism.2022, 33(3):175-185.
3. Cheng H.*, He Y.*, Zhou R.*, Swamp eel (Monopterus albus). Trends in Genetics, 2021, 37(12):1137-1138.
4. Zhang Y., Xu X., Hu M., Wang X., Cheng H.*, Zhou R.*, SPATA33 is an autophagy mediator for cargo selectivity in germline mitophagy. Cell Death Differ., 2021, 28, 1076-1090.
5. Xu X., Zhang Y., Cheng H.*, Zhou R.*, SPATA33 functions as a mitophagy receptor in mammalian germline. Autophagy, 2021, 17(5):1284-1286.
6. Shang D., Wang L., Klionsky DJ., Cheng H.*, Zhou R.*, Sex differences in autophagy-mediated diseases: toward precision medicine. Autophagy, 2021, 17(5):1065-1076..
7. Cheng Y., Lai F., Wang X., Shang D., Zou J., Luo M., Xia X., Cheng H.*, Zhou R.*, Srag regulates autophagy via integrating into a preexisting autophagy pathway in testis. Mol Biol Evol. 2021. 38(1):128-141.
8. Wang X., Lai F., Shang D., Cheng Y., Lan T., Cheng H.*, Zhou R.*, Cellular fate of intersex differentiation. Cell Death Dis., 2021, 12(4):388.
9. Li Z., Li H., Xu X., Wang L., Liu B., Zheng W., Lian L., Song Y., Xia X., Hou L., Cheng H.*, Zhou R.*, Haploinsufficiency of GCP4 induces autophagy and leads to photoreceptor degeneration due to defective spindle assembly in retina. Cell Death Differ. 2020,27(2):556-572.
10. Cheng Y., Shang D., Luo M., Huang C., Lai F., Wang X., Xu X., Ying R., Wang L., Zhao Y., Zhang L., Long M., Cheng H.*, Zhou R.*. Whole genome-wide chromosome fusion and new gene birth in the Monopterus albus genome. Cell Bioscience. 2020,10:67.
11. Zhao Y., Shang D., Ying R., Cheng H.*, Zhou R.*, An optimized base editor with efficient C-to-T base editing in zebrafish. BMC Biol. 2020;18(1):190.
12. Hong Q., Li C., Ying R., Lin H., Li J., Zhao Y., Cheng H.*, Zhou R.*, Loss-of-function of sox3 causes follicle development retardation and reduces fecundity in zebrafish. Protein Cell. 2019, 10(5):347-364.
13. Sheng Y., Song Y., Li Z., Wang Y., Lin H., Cheng H.*, Zhou R.*, RAB37 interacts directly with ATG5 and promotes autophagosome formation via regulating ATG5-12-16 complex assembly. Cell Death Differ. 2018; 25(5):918-934.
14. Song Y., Shang D., Cheng H.*, Zhou R.*, The small GTPase RAB37 functions as an organizer for autophagosome biogenesis. Autophagy. 2018; 14(4): 702-714.
15. Zhao X., Luo M., Li Z., Zhong P., Cheng Y., Lai F., Wang X., Min J., Bai M., Yang Y., Cheng H.*, Zhou R.*, Chromosome-scale assembly of the Monopterus genome. GigaScience. 2018;7(5):1-9.
16. Liu J., Shang D., Xiao Y., Zhong P., Cheng H.*, Zhou R.*, Isolation and characterization of string-forming female germline stem cells from ovaries of neonatal mice. J. Biol. Chem. 2017; 292(39):16003-16013.
17. Luo M., Zhao X., Song Y., Cheng H.*, Zhou R.*, Nuclear autophagy: An evolutionarily conserved mechanism of nuclear degradation in the cytoplasm. Autophagy. 2016;12(11):1973-1983.
18. Xiao Y., Gao M., Gao L., Zhao Y., Hong Q., Li Z., Yao J., Cheng H.*, Zhou R.*, Directed differentiation of zebrafish pluripotent embryonic cells to functional cardiomyocytes. Stem Cell Reports. 2016;7(3):370-82.
19. Yuan J., Zhang Y., Sheng Y., Fu X., Cheng H.*, Zhou R.*, MYBL2 guides autophagy suppressor VDAC2 to the developing ovary to inhibit autophagy through a complex of VDAC2 /BECN1/ BCL2L1 in mammals. Autophagy, 2015, 11(7):1081-1098.
20. Fu X., Cheng Y., Yuan J., Huang C., Cheng H.*, Zhou R.*, Loss-of-function mutation in the X-linked TBX22 promoter disrupts an ETS-1 binding site and leads to cleft palate. Hum. Genet. 2015, 134(2):147-158.
21. Chen K., Huang C., Yuan J., Cheng H.*, Zhou R.*, Long-term artificial selection reveals a role of TCTP in autophagy in mammalian cells. Mol Biol Evol. 2014, 31(8):2194-211.
22. Zuo Z., Peng D., Yin X., Zhou X., Cheng H.*, Zhou R.*, Genome-Wide Analysis Reveals Origin of Transfer RNA Genes from tRNA Halves. Mol Biol Evol. 2013, 30(9):2087-98.
23. Hou Y., Yuan J., Zhou X., Fu X., Cheng H.*, Zhou R.*, DNA Demethylation and USF Regulate the Meiosis-Specific Expression of the Mouse Miwi. PLoS Genet. 2012, 8(5):e1002716.
24. Zhou F., Zhao W., Zuo Z., Sheng Y., Zhou X., Hou Y., Cheng H.*, Zhou R.*, Characterization of androgen receptor structure and nucleocytoplasmic shuttling of the rice field eel. J. Biol. Chem. 2010, 285(47):37030-40.
25. Zhou X., Zuo Z., Zhou F., Zhao W., Sakaguchi Y., Suzuki T., Suzuki T., Cheng H.*, Zhou R.*, Profiling sex-specific piRNAs in zebrafish. Genetics. 2010,186(4):1175-85.
26. Ying M., Chen B., Tian Y., Hou Y., Li Q., Shang X., Sun J., Cheng H.*, Zhou R.*, Nuclear import of human sexual regulator DMRT1 is mediated by importin-β. BBA Mol. Cell Res. 2007, 1773(6):804-813.
27. Huang X., Guo Y., Shui Y., Gao S., Yu H., Cheng H.*, Zhou R.*, Multiple alternative splicing and differential expression of Dmrt1 in gonad transformation during sex reversal of the rice field eel. Biol. Reprod. 2005, 73: 1017–1024.
28. Cheng H., Ying m., Tian Y., Guo Y., McElreavey K., Zhou R.*, Transcriptional diversity of DMRT1 (dsx- and mab3-related transcription factor 1) in human testis. Cell Res. 2006, 16:389-393.
29. 主编 张楚富,副主编 程汉华 刘德立 生物化学原理 高等教育出版社 2011年
30. 程汉华主编 生物化学数字课程 高等教育出版社2018年