学习经历
2005-2009 中国海洋大学国家海洋生命科学与技术人才培养基地,学士
B.S. Biology, Ocean University of China, Qingdao, China
2009-2014 中科院上海生命科学研究院生物化学与细胞生物学研究所,博士
Ph.D. Institute of Biochemistry and Cell Biology, Shanghai Institutes
for Biological Sciences, Chinese Academy of Sciences, Mentor:En-duo Wang
主要工作经历与任职情况
2014-2020 美国希望之城贝克曼研究所(2014-2016)及加州大学圣地亚戈分校(2016-2020),博士后
Post-doctoral research fellow, Beckman Institute of City of Hope and UCSD, Mentor:
Shizhen (Emily) Wang
2020/9- 金沙8888js官方,教授
Professor, College of Life Sciences, Wuhan University, Wuhan, China
主要社会兼职
2020- Lead guest editor for research topic ofFrontiers in Molecular Biosciences, Cells
2018-Reviewer for Signal Transduction and Targeted Therapy, SCIENCE CHINA Life Sciences, Theranostics, Scientific Reports, Cancer Letters, Journal of Experimental & Clinical Cancer Research etc.
2021- 教育部学位中心评审专家, 中国生物物理学会代谢生物学分会青年理事
2023- Editorial Board for BMC Cancer
主要科研奖励和个人荣誉
中国科学院大学-BHPB奖学金(2013)
第十五批中组部海外高层次人才计划青年项目(2018)
“武汉英才”产业领军人才创新类(2021)
Promega/细胞生物学会“Discover Glo Innovator”(2022)
王宽诚教育基金会资助(2022)
承担课程
本科生:细胞生物学(Cell Biology),春季授课,弘毅班 (英文授课)
研究生:细胞生物学研究前沿,秋季授课
担任21级生物科学3班班主任,23级弘毅学堂生物学班学业导师
主持课题项目
国家自然科学基金-面上项目(32270827),2023-2026。
国家自然科学基金-青年科学基金项目(82203590),2023-2025。
中组部高层次人才计划青年项目,2020-2023。
科技部国家重点研发计划“发育编程及其代谢调节”重点专项“分泌蛋白对能量稳态的调控和机制”,2021-2026 (课题骨干)。
主要研究领域及兴趣
在生物体内,细胞外囊泡(Extracellular Vesicles, EV)参与细胞与细胞之间的相互通讯。其中,外泌体是直径介于30-150 nm的一种EV,内包含蛋白质,mRNA及非编码RNA等活性成分。外泌体在肿瘤及免疫代谢疾病中参与重要的调节作用,并有望成为早期肿瘤诊断的标记物。肿瘤细胞分泌的外泌体可进入血液循环系统,从而对肿瘤微环境及远程器官具有一定的调节作用, 然而其对于肿瘤的发生及转移有无影响以及其中的调控机制尚未清楚。我们课题组主要从事肿瘤以及免疫细胞来源的外泌体对肿瘤在代谢及表观遗传层面的调控,将从细胞层面,小鼠模型及病人样本层面对肿瘤分泌的外泌体进行系统性的研究,结合单细胞测序以及质谱学探索外泌体活性成分对肿瘤微环境及各组织器官的调控机制,从而筛选出对肿瘤发生及转移重要的标记物。并进一步根据这些标记物设计出小分子抑制剂,从而服务于肿瘤的早期诊断并为治疗提供相应的科研基础。
发表的论文(*通讯作者)
1)Hu S#, Zhang XH#, Yan W*. Isolation and characterization of small extracellular vesicles from murine primary mammary tumor. STAR Protoc. 2023 Dec 15;5(1):102783. doi: 10.1016/j.xpro.2023.102783. PMID: 38103192.
2)Zhang XH#, Zhao YX#, Yan W*. The role of extracellular vesicles in skeletal muscle wasting. Journal of Cachexia, Sarcopenia and Muscle 2023 Oct 22. doi: 10.1002/jcsm.13364. PMID: 37867162.
3)Hu Y#, Liu L#, Chen Y, Zhang XH, Zhou HF, Hu S, Li X, Li MX, Li JJ, Cheng SY, Liu Y, Xu YC*, Yan W*. Cancer-cell-secreted miR-204-5p induces leptin signaling pathway in white adipose tissue to promote cancer-associated cachexia. Nature Communications 2023 Aug 24;14(1):5179. doi: 10.1038/s41467-023-40571-9. PMID: 37620316.
4)Hu S#, Hu Y#, Yan W*. Extracellular vesicle-mediated interorgan communication in metabolic diseases. Trends in Endocrinology and Metabolism. 2023 Sep;34(9):571-582. doi: 10.1016/j.tem.2023.06.002. PMID: 37394346.
5)Li MX#, Wu XT#, Jing WQ#, Hou WK, Hu S, Yan W*. Inosine enhances tumor mitochondrial respiration by inducing Rag GTPases and nascent protein synthesis under nutrient starvation. Cell Death Dis. 2023 Aug 2;14(8):492. doi: 10.1038/s41419-023-06017-2. PMID: 37532694.
6)Yan W*, Cao M, Ruan X, Jiang L, Lee S, Lemanek A, Ghassemian M, Pizzo DP, Wan Y, Qiao Y, Chin AR, Duggan E, Wang D, Nolan JP, Esko JD, Schenk S*, Wang SE*. Cancer-cell-secreted miR-122 suppresses O-GlcNAcylation to promote skeletal muscle proteolysis. Nat Cell Biol. 2022 May;24(5):793-804. doi: 10.1038/s41556-022-00893-0. Epub 2022 Apr 25. PMID: 35469018; PMCID: PMC9107513.
7)Yan W*, Jiang S*. Immune Cell-Derived Exosomes in the Cancer-Immunity Cycle. Trends in Cancer. 2020 March 17; DOI: https://doi.org/10.1016/j.trecan.2020.02.013. PMID: 3246000.
8)Yan W, Wu X, Zhou W, Fong MY, Cao M, Liu J, Liu X, Chen CH, Fadare O, Pizzo DP, Wu J, Liu L, Liu X, Chin AR, Ren X, Chen Y, Locasale JW, Wang SE*. Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells. Nat Cell Biol. 2018 May;20(5):597-609. PubMed PMID:29662176; PubMed Central PMCID: PMC5920728.
9)Jiang S#, Yan W#, Wang SE*, Baltimore D*. Let-7 Suppresses B Cell Activation through Restricting the Availability of Necessary Nutrients. Cell Metabolism. 2018 Feb 6;27(2):393-403.e4. PubMed PMID:29337138.
10)Yan W, Ye Q, Tan M, Chen X, Eriani G, Wang ED*. Modulation of Aminoacylation and Editing Properties of Leucyl-tRNA Synthetase by a Conserved Structural Module. J Biol Chem. 2015 May 8;290(19):12256-67. PubMed PMID:25817995; PubMed Central PMCID: PMC4424357.
11)Yan W#, Tan M#, Eriani G, Wang ED*. Leucine-specific domain modulates the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase. Nucleic Acids Res. 2013 May;41(9):4988-98. PubMed PMID:23525458; PubMed Central PMCID: PMC3643597.
12)Tan M#, Yan W#, Liu RJ, Wang M, Chen X, Zhou XL, Wang ED*. A naturally occurring nonapeptide functionally compensates for the CP1 domain of leucyl-tRNA synthetase to modulate aminoacylation activity. Biochem J. 2012 Apr 15;443(2):477-84. PubMed PMID:22292813.
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