Education
2002.9 - 2007.7 Ph.D.
Biochemistry and Molecular Biology, Institute of Biophysics, Chinese Academy of Sciences.
1998.9 - 2002.7 B.S.
Biology Science, Wuhan University, Wuhan, China.
Work Experience
2013 - Present：Professor and Doctoral Supervisor, College of Life Sciences, Wuhan University, Wuhan, China.
2007 - 2013 Research associate，Howard Hughes Medical Institute, National Jewish Health，US.
Research Interests
Molecular Mechanisms of Pathogen Recognition by Immune System.
Structure Based Immunotherapy
Research Grants and Funding
Principle Investigator for grants from National Science Foundation of China
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elected Recent Publications
1. Wei Pengcheng, Yang Yi, Liu Zhaoxin, Luo Zuoqin, Tu Wenya, Han Junyan, Deng Yunhua, Yin Lei*. (2017) Characterization of Autoantigen Presentation by HLA-C*06:02 in Psoriasis. Journal of Investigative Dermatology (Accepted)
2. Xiao X, Tang JJ, Peng C, Wang Y, Fu L, Qiu ZP, Xiong Y, Yang LF, Cui HW, He XL,Yin L, Qi W, Wong CL, Zhao Y, Li BL, Qiu WW*, Song BL*. (2017) Cholesterol modification of Smoothened is required for hedgehog signaling. Molecular Cell 66:1-9
3. Hu MM, Yang Q, Xie XQ, Liao CY, Lin H, Liu TT, Yin L, Shu HB*.（2016）Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus. Immunity. 2016 Sep 20;45(3):555-69.
4.Xia H, Wang P, Wang GC, Yang J, Sun X, Wu W, Qiu Y, Shu T, Zhao X, Yin L, Qin CF, Hu Y, Zhou X*. (2015) Human Enterovirus Nonstructural Protein 2CATPase Functions as Both an RNA Helicase and ATP-independent RNA Chaperone. PLOS Pathogens, 11(7): e1005067. doi: 10.1371/journal.ppat.1005067.
5. Yang J, Cheng Z, Zhang S, Xiong W, Xia H, Qiu Y, Wang Z, Wu F, Qin CF, Yin L, Hu Y and Zhou X* .A Cypovirus VP5 Displays the RNA Chaperone-like Activity that Destabilizes RNA Helices and Accelerates Stranding Annealing. Nucleic Acids Research, 2014 .42(4): 2538-2554.
6.Yin,L.*, Dai,S., Clayton, G.,Gao, W., Wang,Y., Kappler,J., Marrack P.* Recognition of self and altered self by T cells in autoimmunity and allergy. Protein & cell 2013 Jan;4(1):8-16 (Invited Review)(* Corresponding)
7.Yin,L., Crawford,F., Marrack,P., Kappler,J., Dai, S. T-cell receptor(TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy. PNAS（Proceedings of the National Academy of Sciences）2012 Nov 6;109(45):18517-22 Recommended by Faculty of 1000.
8.Yin,L., Scott-Browne,J., Kappler,J., Gapin, L., Marrack,P. T cells and their eons-old obsession with MHC. Immunological Reviews 2012 Nov; 250(1):49-60. (Invited Review)
9.Yin,L.*, Huseby, E.*, Scott-Browne,J., Rubtsova,K., Pinilla,C., Crawford,F., Marrack, P., Dai, S., Kappler,J. A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers. Immunity. 2011 Jul 22;35(1):23-33(* Contributed equally) Recommended by Immunity 35:1-3,2011. Recommended by Faculty of 1000.
10.Hu Y*, Gai Y*, Yin L*, Wang X, Feng C, Feng L, Li D, Jiang XN, Wang DC. Crystal structures of a Populus tomentosa 4-coumarate:CoA ligase shed light on its enzymatic mechanisms. Plant Cell. 2010 Sep;22(9):3093-104.(* Contributed equally)
11.Yin,L.,Xiang,Y.,Zhu,D.Y.,Yan,N.,Huang,Q.H., Wang,D.C. Crystal structure of human SH3BGRL protein: the first structure of the human SH3BGR family representing a novel class of thioredoxin fold proteins. Proteins. 2005 61：213－216.
12.Zhu,Y.Q., Zhu,D.Y., Yin,L., Zhang,Y., Vonrhein,C., Wang,D.C. Crystal structure of human spermidine/spermine N1-acetyltransferase (hSSAT): The first structure of a new sequence family of transferase homologous superfamily. Proteins. 2006 63:1127-1131.
13.Yin,L.,Zhu,D.Y.,Yan,N.,Huang,Q.H., Wang,D.C. Expression, purification, and crystallization of a human protein SH3BGRL with atomic resolution. Acta Cryst. F. 2005 61, 384-386.
