Min Wu
Min Wu, PhD
Professor
College of Life Sciences, Wuhan University
Phone: 027-68756620
Email: wumin@whu.edu.cn
Education:
1999-2004 Ph. D
College of Life Sciences, Peking University
1995-1999 B.S.
College of Life Sciences, Peking University
Beijing, China
Research Experience:
2009.3- Professor
College of Life Sciences, Wuhan University
2007-2009 Post Dr. Research Asso.
Shilatifard Lab, Stowers Institute for Medical Research
2004-2007 Post Dr. Asso.
School of Medicine, Yale University
2001-2002 Visiting Student
National Jewish Medical and Research Center
Research Interests
a. The mechanisms of epigenetics regulation and its relationship with cancer.
Epigenetics factors, especially histone modifications and their enzymes, emerged to be one of the most important aspects in gene expression regulation and chromatin remodeling. It determines the fate of all the cells and controls their physiological functions, such as stem cell renewal, differentiation and tumor formation. Our lab is interested how histone methylation and methyltransferases, together with other modification factors, regulate gene expression and tumorigenesis.
b. The regulation of NF-kappaB and p53 pathways by protein modifications.
Not only histones are massively modified, other proteins, like important transcription factors p53 and NF-kappaB, are also modified by methylation, acetylation, phosphorylation and ubiquitination. Each modification has its unique important function. Our lab is investigating the modifications on p53 and NF-kappaB by proteomics and molecular biology techniques, and their role in cancer development.
Representative Publications:
Min Wu*, Peng Fei Wang*, Jung Shin Lee, Skylar Martin-Brown, Laurence Florens, Michael Washbrun and Ali Shilatifard. Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS. Mol Cell Biol. 2008 Dec;28(24):7337-44. (*contributed equally to this study).
Leigh Ann Higa*, Min Wu*, Tao Ye, Ryuji Kobayashi, Hong Sun and Hui Zhang. CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. Nat Cell Biol. 2006 Nov;8(11):1277-83. ( *contributed equally to this study).
Damon Banks*, Min Wu*, Leigh Ann Higa, Nadia Gavrilova, Junmin Quan, Tao Ye, Ryuji Kobayashi, Hong Sun, Hui Zhang. L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes. Cell Cycle. 2006 Aug;5(15):1719-29. (*contributed equally to this study).
Min Wu, Liang-Guo Xu, Tian Su, Yang Tian, Jun Huang, Zhonghe Zhai, Hong-Bing Shu. AMID is a p53-inducible gene down-regulated in tumors. Oncogene, 2004, vol. 23, 6815-6819.
Min Wu, Liang-Guo Xu, Zhonghe Zhai and Hong-Bing Shu. SINK is a p65-interacting Negative Regulator of NF-κB-dependent Transcription. Journal of Biological Chemistry, 2003, Vol. 278, 27072-27079.
Min Wu*, Liang-Guo Xu*, Xiaoyan Li, Zhonghe Zhai and Hong-bing Shu. AMID, an apoptosis-inducing factor-homologous mitochondrion-associated protein, induces caspase-independent apoptosis. Journal of Biological Chemistry, 2002, Vol. 277, 25617-25623. (*contributed equally to this study).
Liang-Guo Xu*, Min Wu*, Jiancheng Hu, Zhonghe Zhai and Hong-Bing Shu. Identification of downstream genes up-regulated by the tumor necrosis factor member TALL-1. Journal of Leukocyte Biology 2002, Vol. 72, 410-416. (*contributed equally to this study).
Min Wu, Yun Zhao, Zhonghe Zhai. The ultrastructural observation of apoptotic mouse liver cell nuclei. Journal of Chinese Electron Microscopy Society 2001, Vol. 20, No.1, 21-26.
