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Zhiyin Song

Professor  

Department of Cell Biology

Research Fields: Mitochondrial dynamics and human diseases

Laboratory: Room 4122, Building of College of Life Sciences

Tel: 027-68752235

E-mail: songzy@whu.edu.cn

EDUCATION AND CAREER

2011.1 ~ Present:  Professor, College of Life Sciences at Wuhan University

2005.8 ~ 2010.12: California Institute of Technology, Postdoctoral Research Associate,

2000.9 ~ 2005.7:  School of Life Sciences, University of Science and Technology of China; Major: Molecular Cell Biology; Degree: Ph.D.

1995.9 ~ 1999.7:  School of Life Sciences, AnHui University; Major: Biological Chemistry; Degree: Bachelor

RESEARCH INTERESTS

Mitochondria are the major energy source and key regulatory center of apoptosis in mammalian cells. Mitochondria are highly dynamic organelles that continuously divide and fuse. Mitochondrial dynamics determine the morphology, structure and function of mitochondria within the cell. Abnormal mitochondrial dynamics leads to various human diseases including neurodegenerative diseases, cardiovascular diseases and cancers. We focus on the role of mitochondrial dynamics in normal cellular function and human diseases. To address these issues, we will develop some novel technologies for mitochondrial research, and create some mice models to study the occurrence and development of mitochondria associated human diseases.

SELECTED PUBLICATIONS

1. Shu L#, Hu C#, Xu M, Yu J, Lin J, Sha H, Lu B, Engelender S, Guan M, Song Z*. (2021) ATAD3B is a Mitophagy Receptor Mediating Clearance of Oxidative Stress-induced Damaged mtDNA. EMBO Journal. (In Press)

2. Wu Z#, Zuo M#, Zeng L, Cui K, Yan C, Chen L, Dong J, Shangguan F, Hu W, He H, Lu B, Song Z*. (2021) OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development. EMBO Reports. 22(1):e50827

3. Junhui Tang#, Kuan Zhang#, Jun Dong, Chaojun Yan, Chao Hu, Hongchao Ji, Liangyi Chen, Shi Chen, Huabin Zhao, Zhiyin Song*. (2020) Sam50-Mic19-Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact.Cell Death and Differentiation. 27(1):146-160 

4. Chaojun Yan, Longlong Gong, Li Chen, Meng Xu, Hussein Abou-Hamdan, Mingliang Tang, Laurent Désaubry, Zhiyin Song* (2020) PHB2 (prohibitin 2) promotes PINK1-PRKN/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis. Autophagy. 16(3):419-434

5. Chao Hu, Li Shu, Xiaoshuai Huang, Jianglong Yu, liuju Li, Longlong Gong, Meigui Yang, Zhida Wu, Zhi Gao, Yungang Zhao, Liangyi Chen*, and Zhiyin Song* (2020) OPA1 and MICOS Regulate Mitochondrial Crista Dynamics and Formation. Cell Death & Disease. 11(10):940

6. Chaojun Yan, Xiaoying Duanmu, Ling Zeng, Bing Liu, Zhiyin Song*. (2019) Mitochondrial DNA: Distribution, Mutations, and Elimination. Cells. 8(4). pii: E379. doi: 10.3390/cells8040379. Review.

7. Fenglei Jian, Dan Chen, Li Chen, Chaojun Yan, Bin Lu, Yushan Zhu, Shi Chen, Anbing Shi, David C Chan, Zhiyin Song.* (2018) Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology. Cell Reports. 23(10), 2989-3005

8. Muhammad Riaz Khan, Shaoxun Xiang, Zhiyin Song*, Mian Wu* (2017) The p53-inducible long noncoding RNA TRINGS protects cancer cells from necrosis under glucose starvation. EMBO Journal. 36(23):3483-3500

9. Li H, Ruan Y, Zhang K, Jian F, Hu C, Miao L, Gong L, Sun L, Zhang X, Chen S, Chen H, Liu D, Song Z.* (2016) Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization. Cell Death and Differentiation, 23(3):380-92.

10. Kuan Zhang, Huihui Li, Zhiyin Song* (2014) Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage. EMBO Reports, 15(5):576-85

11. Y Ruan, H Li, K Zhang, F Jian, J Tang, Z Song* (2013) Loss of Yme1L perturbates mitochondrial dynamics. Cell Death & Disease, 4:e896. 

12. Miao L#, Song Z#, Jin L, Zhu YM, Wen LP, Wu M. (2010) ARF antagonizes the ability of Miz-1 to inhibit p53-mediated transactivation. Oncogene, 29(5):711-722

13. Song Z, Ghochani M, McCaffery JM, Frey TG, Chan DC. (2009) Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion. Molecular Biology of the Cell, (15):3525-3532

14. Song Z, Chen H, Fiket M, Alexander C, Chan DC. (2007) OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L. Journal of Cell Biology. 178(5):749-755

15. Song Z, Wu M. (2005) Identification of a novel nucleolar localization signal and a degradation signal in Survivin-deltaEx3: a potential link between nucleolus and protein degradation. Oncogene. 14; 24(16): 2723-2734

16. Song Z, Liu S, He H, Hoti N, Wang Y, Feng S, Wu M. (2004) A Single Amino Acid Change (Asp 53->Ala53) Converts Survivin from anti-apoptotic to pro-apoptotic. Molecular Biology of the Cell. 15(3):1287-1296

17. Song Z, Yao X, Wu M. (2003) Direct interaction between Survivin and Smac is essential for the anti-apoptotic activity of Survivin during Taxol-induced apoptosis. Journal of Biological Chemistry. 278(25): 23130-23140