Professor, Principle Investigator
Department of Virology, College of Life Sciences
Department of Immunology, Medical Research Institute
Wuhan University, Wuhan, China, 430072
Tel: 86-27-68752202
Fax: 86-27-68752246
Email: zhongbo@whu.edu.cn
Research Area
Innate antiviral immunity, Inflammation and tumorigenesis
Education
2001.9－2005.6 B.A. in English
Foreign Languages Department
China University of Geosciences, Wuhan, China
2003.2－2005.6 B.S. in Biology
College of Life Sciences
Wuhan University, Wuhan, China
2005.9－2010.6 Ph.D. in Cell and Developmental Biology
College of Life Sciences
Wuhan University, Wuhan, China
Employment
2010.7－2013.5 Postdoctoral Fellow
Department of Immunology
Center for Inflammation and Cancer
The University of Texas
MD Anderson Cancer Center, Houston, TX
2013.3－now Professor
College of Life Sciences
Medical Research Institute
Wuhan University, Wuhan, China
Awards and Honors
2017 Chinese Society of Cell Biology, CST-Young Investigator Award
2016 Zhu Yu-Bi Medical Research Award, Wuhan University
2015 National Natural Science Award, China
2015 One of Ten Excellent Young Faculties of Wuhan University, China
2014 One Thousand Youth Talents Project, China
2012 National Excellent Doctoral Dissertation, Ministry of Education, China
2012 Abstract Award, American Association of Immunologists, USA
2011 Odyssey Fellowship, MD Anderson Cancer Center
2010 Invited to the 60th Lindau Nobel Laureates Meeting, Germany
2009 The Ray Wu Prize Fellow, The Ray Wu Memorial Fund, USA (http://www.raywumemorialfund.org/2009winner.php)
Research Interest
Protein ubiquitination and deubiquitination plays diverse roles in signaling transduction, development, immunity and inflammation. Dr. Zhong’s lab works on ubiquitination and deubiqutination process during innate antiviral immune and inflammatory responses and tumorigenesis. His lab focuses on E3 ligases and deubiquitinases that regulate virus-triggered immune signaling and elucidates the mechanisms with gene-knockout mice and the related disease models.
Publications
1. Li SZ*, Shu QP, Song Y, Zhang HH, Liu Y, Jin BX, Liuyu TZ, Li C, Huang XC, Du RL, Song W*, Zhong B*, Zhang XD*. Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response. Nat Commun, 2019, 10(1): 3233.
2. Liu X*, Wang Y, Lu H, Li J, Yan X, Xiao M, Hao J, Alekseev A, Khong H, Chen T, Huang R, Wu J, Zhao Q, Wu Q, Xu S, Wang X, Jin W, Yu S, Wang Y, Wei L, Wang A, Zhong B, Ni L, Liu X, Nurieva R, Ye L, Tian Q, Bian XW*, Dong C*. Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction. Nature, 2019, 567(7749): 525-529.
3. Ye L#, Zhang Q#, Liuyu T, Xu Z, Zhang MX, Luo MH, Zeng WB, Zhu Q, Lin D*, Zhong B*. USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA. Plos Pathog, 2019, 15(4): e1007680.
4. Zhang MX, Cai Z, Zhang M, Wang XM, Wang Y, Zhao F, Zhou J, Luo MH, Zhu Q, Xu Z, Zeng WB*, Zhong B*, Lin D*. USP20 promotes cellular antiviral responses via deconjugating K48-linked ubiquitination of MITA. J Immunol, 2019, 202(8):2397-2406.
5. Liuyu T, Yu K, Ye L, Zhang Z, Zhang M, Ren Y, Cai Z, Zhu Q, Lin D, Zhong B*, Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS. Cell Res, 2019, 29(1):67-79.
6. Zhao Y, Wang XM, Wang Q, Deng Y, Li K, Zhang M, Zhang Q, Zhou J, Wang HY, Bai P, Ren Y, Zhang N, Li W, Cheng Y, Xiao W, Du HN, Cheng X, Yin L, Fu X, Lin D, Zhou Q, Zhong B*, USP2a supports metastasis by tuning TGF-b signaling. Cell Rep, 2018, 22(9):2442-2454.
7. Li K, Zhong B*, Regulation of cellular antiviral signaling by modifications of ubiquitin and ubiquitin-like molecules. Immune Network. 2018, 18(1):e4. (Invited review)
8. Lu B#, Ren Y#, Sun X#, Han C, Wang H, Chen Y, Peng Q, Cheng Y, Cheng X, Zhu Q, Li W, Li HL, Du HN, Zhong B*, Huang Z*. Induction of INKIT by viral infection negatively regulates antiviral responses through inhibiting phosphorylation of p65 and IRF3. Cell Host Microbe, 2017, 22(1):86-98.e4. (Cover story)
9. Sun H#, Zhang Q#, Jing YY, Zhang M, Wang HY, Cai Z, Liuyu T, Zhang ZD, Xiong TC, Wu Y, Zhu QY, Yao J, Shu HB, Lin D, Zhong B*. USP13 negatively regulates antiviral responses by deubiquitinating STING. Nat Commun. 2017, May 23; 8:15534. 10.1038/NCOMMS15534.
10. Wang X, Ni L, Chang D, Lu H, Jiang Y, Kim BS, Wang A, Liu X, Zhong B, Yang X, Dong C. Cyclic AMP-Responsive Element-Binding Protein (CREB) is Critical in Autoimmunity by Promoting Th17 but Inhibiting Treg Cell Differentiation. EBioMedicine, 2017, 25: 165-174.
11. Zhang M#, Zhang MX#, Zhang Q, Zhu GF, Yuan L, Zhang DE, Zhu QY, Yao J, Shu HB, Zhong B*. USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA. Cell Res. 2016, 26(12): 1302-1319.
12. Ren Y, Zhao Y, Lin D, Xu X, Zhu Q, Yao J, Shu HB, Zhong B*. The type I IFN-IRF7 axis mediates virus-triggered upregulation of Usp25 gene. J Biol Chem. 2016, 291(25): 13206-13215.
13. Lin D, Zhang M, Zhang MX, Ren YJ, Zhao Q, Jin J, Pan Z, Wu M, Shu HB, Dong C, Zhong B*. Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6. Proc Natl Acad Sci U S A. 2015 112(36):11324-329.
14. Lin D, Zhong B*. Regulation of cellular innate antiviral signaling by ubiquitin modification. Acta Biochim Biophys Sin. 2015 47(3):149-155. (Invited Review)
15. Wang X, Ni L, Chang D, Lu H, Jiang Y, Kim BS, Wang A, Liu X, Zhong B, Yang X, Dong C*. Cyclic AMP-Responsive Element-Binding Protein (CREB) is Critical in Autoimmunity by Promoting Th17 but Inhibiting Treg Cell Differentiation. EBioMedicine. 2017, 25:165-174. doi: 10.1016/j.ebiom.2017.10.010.
16. Zhu Y, Gu L, Li Y, Lin X, Shen H, Cui K, Chen L, Zhou F, Zhao Q, Zhang J, Zhong B, Prochownik E, Li Y*. miR-148a inhibits colitis and colitis-associated tumorigenesis in mice. Cell Death Differ. 2017, 24(12):2199-2209.
17. Yang Q, Liu TT, Lin H, Zhang M, Wei J, Luo WW, Hu YH, Zhong B, Hu MM*, Shu HB*. TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses. PLoS Pathog. 2017, 13(9):e1006600.
18. Cheng L, Ren Y, Lin D, Peng S, Zhong B, Ma Z. The Anti-Inflammatory Properties of Citrus wilsonii Tanaka Extract in LPS-Induced RAW 264.7 and Primary Mouse Bone Marrow-Derived Dendritic Cells. Molecules. 2017, 22(7). pii: E1213
19. Qiu Y, Xu Y, Zhang Y, Zhou H, Deng YQ, Li XF, Miao M, Zhang Q, Zhong B, Hu Y, Zhang FC, Wu L, Qin CF*, Zhou X*. Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals. Immunity. 2017, 46(6):992-1004.e5.
20. Peng Q, Lan X, Wang C, Ren Y, Yue N, Wang J, Zhong B, Zhu Q. Kobuvirus VP3 protein restricts the IFN-β-triggered signaling pathway by inhibiting STAT2-IRF9 and STAT2-STAT2 complex formation. Virology. 2017 Apr 22; 507:161-169.
21. Wang A, Ding X, Demarque M, Liu X, Pan D, Xin H, Zhong B, Wang X, Dejean A, Jin W, Dong C. Ubc9 Is Required for Positive Selection and Late-Stage Maturation of Thymocytes. J Immunol. 2017 May 1; 198(9):3461-3470.
22. Gao SF, Zhong B, Lin D*. Regulation of T helper cell differentiation by E3 ubiquitin ligases and deubiquitinating enzymes. Int Immunopharmacol. 2017, 42:150-156.
23. Wang J, Lei CQ, Ji Y, Zhou H, Ren Y, Peng Q, Zeng Y, Jia Y, Ge J, Zhong B, Li Y, Wei J, Shu HB, Zhu Q. Duck Tembusu Virus Nonstructural Protein 1 Antagonizes IFN-β Signaling Pathways by Targeting VISA. J Immunol. 2016, 197(12):4704-4713.
24. Luo WW, Li S, Li C, Lian H, Yang Q, Zhong B, Shu HB. iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING. Nat Immunol. 2016, 17(9): 1057-66.
25. Liu TT, Yang Q, Li M, Zhong B, Ran Y, Liu LL, Yang Y, Wang YY, Shu HB. LSm14A Plays a Critical Role in Antiviral Immune Responses by Regulating MITA Level in a Cell-Specific Manner. J Immunol. 2016 196(12):5101-11.
26. An T, Li S, Pan W, Tien P, Zhong B, Shu HB, Wu S. DYRK2 Negatively Regulates Type I Interferon Induction by Promoting TBK1 Degradation via Ser527 Phosphorylation. PLoS Pathog. 2015 11(9): e1005179.
27. Wei J, Lian H, Zhong B, Shu HB. Parafibromin is a component of IFNγ-triggered signaling pathways that facilitates JAK1/2-mediated tyrosine phosphorylation of STAT1. J Immunol. 2015 195(6):2870-8.
28. Deng T, Lin D, Zhang M, Zhao Q, Li W, Zhong B, Deng Y, Fu X. Differential expression of bone morphogenetic protein 5 in human lung squamous cell carcinoma and adenocarcinoma. Acta Biochim Biophys Sin. 2015 47(7):557-63.
29. Liu X, Chen X, Zhong B, Wang A, Wang X, Chu F, Nurieva RI, Yan X, Chen P, van der Flier LG, Nakatsukasa H, Neelapu SS, Chen W, Clevers H, Tian Q, Qi H, Wei L, Dong C. Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development. Nature. 2014, 507(7493):513-8.
30. Luo WW, Lian H, Zhong B, Shu HB, Li S. Krüppel-like factor 4 negatively regulates cellular antiviral immune response. Cell Mol Immunol. 2016, 13(1):65-72.
31. Zhou Q, Lin H, Wang S, Wang S, Ran Y, Liu Y, Ye W, Xiong X, Zhong B, Shu HB, Wang YY. The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling. Cell Host Microbe. 2014, 16(4):450-61.
32. Qin Y, Zhou MT, Hu MM, Hu YH, Zhang J, Guo L, Zhong B, Shu HB. RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms. PLoS Pathog. 2014, 10(9):e1004358.
33. Lei CQ, Zhang Y, Li M, Jiang LQ, Zhong B, Kim YH, Shu HB. ECSIT Bridges RIG-I-Like Receptors to VISA in Signaling Events of Innate Antiviral Responses. J Innate Immun. 2015, 7(2):153-64.
34. Zhang Y, Lei CQ, Hu YH, Xia T, Li M, Zhong B, Shu HB. Krüppel-like factor 6 is a co-activator of NF-κB that mediates p65-dependent transcription of selected downstream genes. J Biol Chem. 2014, 289(18):12876-85.
35. Hu MM, Yang Q, Zhang J, Liu SM, Zhang Y, Lin H, Huang ZF, Wang YY, Zhang XD, Zhong B, Shu HB. TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3. Proc Natl Acad Sci U S A. 2014, 111(4):1509-14.
36. Lei CQ, Zhang Y, Xia T, Jiang LQ, Zhong B, Shu HB. FoxO1 negatively regulates cellular antiviral response by promoting degradation of IRF3. (2013). J Biol Chem. 288, 12596-604.
37. Zhong B, Liu XK, Wang XH, Liu XD, Li HX, Darnay BR, Lin X, Sun SC and Dong C. Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune response through deubiquitination of TRAF3. (2013). Sci Signal. 6, ra35.
38. Liu XK#, Li HX#, Zhong B#, Blonska M, Gorjestani S, Yan M, Tian Q, Zhang DE, Lin X and Dong C. USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. (2013). J Exp Med. 210, 1575-90. (#Co-first authors)
39. Zhong B, Liu XK, Wang XH, Chang SH, Liu XD, Wang AB, Reynolds JM, and Dong C. Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25. (2012). Nat Immunol. 13, 1110-17.
40. Liu XD, Yan X, Zhong B, Nurieva RI, Wang A, Wang X, Martin-Orozco N, Wang Y, Chang SH, Esplugues E, Flavell RA, Tian Q, Dong C. Bcl6 expression specifies the T follicular helper cell program in vivo. (2012). J Exp Med. 209:1841-52.
41. Xu T#, Wang X#, Zhong B, Nurieva RI, Ding S, Dong C. Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein. (2011). J Biol Chem. 286, 22707-10.
42. Lei CQ, Zhong B, Zhang Y, Zhang J, Wang S and Shu HB. Glycogen synthase kinase 3β regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1. (2010). Immunity. 33, 878-89.
43. Zhong B, Zhang Y, Tan B, Liu TT, Wang YY and Shu HB. The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation. (2010). J Immunol. 184, 6249-6255.
44. Zhong B, Wang YY and Shu HB. Regulation of virus-triggered type I interferon signaling by cellular and viral proteins. (2010). Frontier in Biology 5, 12-31.
45. Zhong B, Zhang L, Lei CQ, Li Y., Mao AP, Yang Y, Wang YY, Zhang XL and Shu HB. The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. (2009). Immunity 30, 397-407.
46. Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao FC, Lei CQ, He X, Zhang L, Tien, P and Shu HB. The adapter protein MITA links virus-sensing receptors to IRF3 transcription factor activation. (2008). Immunity 29, 538–550.
47. Zhong B, Tien P and Shu HB. Innate immune responses: crosstalk of signaling and regulation of gene transcription. (2006). Virology 352, 14-21.
48. Wang YY, Liu LJ, Zhong B, Liu TT, Li Y, Yang Y, Ran Y, Li S, Tien P and Shu HB. WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kB activation. (2010). Proc Natl Acad Sci U S A. 107, 815-820.
49. Mao AP, Li S, Zhong B, Li Y, Yan J, Li Q and Shu HB. Virus-triggered ubiquitination of TRAF3 by cIAP1/2 at the mitochondria is essential for induction of IFN-b and cellular antiviral response. (2010). J Biol Chem. 285, 9470-9476.
50. Chen R, Zhang L, Zhong B, Tan B, Liu Y and Shu HB. Ubiquitin-specific protease 17 is involved in virus-triggered type I interferon signaling. (2010). Cell Res. 20: 802-11.
51. Li S, Zheng H, Mao AP, Zhong B, Li Y, Liu Y, Gao Y, Ran Y, Tien P and Shu HB. Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6. (2010). J Biol Chem. 285, 4291-4297.
52. Li Y, Li C, Xue P, Zhong B, Mao AP, Ran Y, Chen H, Wang YY, Yang FQ and Shu HB. ISG56 is a negative regulator of virus-triggered signaling and cellular antiviral response. (2009). Proc Natl Acad Sci U S A. 106, 7945-50.
53. Daio FC, Li S, Tian Y, Zhang M, Xu LG, Zhang Y, Wang RP, Zhai Z, Zhong B, Tien P and Shu HB. Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxya. (2007). Proc Natl Acad Sci U S A. 104, 11706-11711.
54. Tian Y#, Zhang Y#, Zhong B, Wang YY, Diao FC, Wang RP, Zhang M, Chen DY, Zhai Z and Shu HB. RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. (2007). J Biol Chem. 282, 16776-11782. (#Co-first authors).
55. 张煜，钟波，杨艳，舒红兵. TLRs与RLRs介导的细胞抗病毒反应信号转导及其调节机制. (2009). 细胞生物学杂志 31, 453-468.
56. 钟波，舒红兵. 天然免疫模式识别受体与树突状细胞的发现和意义——2011年诺贝尔生理学或医学奖成果和相关研究. 生命科学 (2011). 23, 1147-1161.
