Lianyun Li
Position: Associate Professor (Biochemistry)
Lab: Room 5003/5005
Office Phone: 86-27-68756620
Lab Phone: 86-27-68756672
Email: lilianyun@whu.edu.cn
Education
2000-2005 Ph.D., Department of Cell Biology and Genetics, Peking University,
1994-1998 B.S., Department of Biotechnology, Sichuan University
Professional Experience
2009-Present Associate Professor, Wuhan University
2005-2009 Postdoctoral fellow, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
Research Interests
1. The connections between protein degradation and signal transduction, epigenetics.
2. Molecule mechanisms of ER-associated protein degradation.
Selected Publications
1. Lian-Yun Li, Nia Soetandyo, Qiu-Yan Wang, Yi-Hong Ye. The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation. Biochim Biophys Acta- Molecular Cell Research. 2009 1793:346-53
2. Lian-Yun Li, Dale Hailey, Nia Soetandyo, Wei Li, Jennifer Lippincott-Schwartz, Hong-Bing Shu, Yi-Hong Ye. Localization of A20 to a lysosome-associated compartment and its role in NF-kappaB signaling. Biochim Biophys Acta- Molecular Cell Research. 2008 1783:1140-9
3. Lian-Yun Li, Liang-Hua Bin, Fu Li, Yi Liu, Dan-Ying Chen, Zhong-He Zhai and Hong-Bing Shu. TRIP6 is a RIP2-associated common signaling component of multiple NF-kappaB activation pathways. J. Cell Sci. 2005 118:555-63
4. Yan-Yi Wang*, Lian-Yun Li*, Ke-Jun Han, Zhong-He Zhai and Hong-Bing Shu. A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter. FEBS Letter. 2004 576:86-90 (*They are co-first authors)
