【Postdoc Positions Focusing on Gene Regulation in Cancer Progression】

发布时间 : 2017/05/09点击量:

这位老师原来是付向东老师的博后,经费很充足。

Multiple postdoctoral positions are available in the laboratory of Dr. Jason Liu

(http://molecularmedicine.uthscsa.edu/FAC_Research.aspx?facID=206) in the Department of

Molecular Medicine at the University of Texas Health Science Center at San Antonio

(UTHSCSA). The focus of the lab is studying enhancer function and epigenetic mechanism in gene

regulation in cancer progression. Selected candidates will perform highly interdisciplinary and

collaborative scientific research in one or more of the following projects, working with human cell lines,

mouse models and clinical samples:

(1) Explore the function of signaling-regulated enhancers in breast and prostate cancers, and

understand how enhancers are regulated by the crosstalk of different signaling pathways including

sex hormones, inflammation signals and metabolic signals;

(2) Decipher the epigenetic and chromatin 3D level changes in enhancers upon

developmental/pathological stimuli or during hormone/drug resistance acquisition;

(3) Identify diagnostic/prognostic biomarkers and therapeutic targets for cancer and develop drugs for

pre-clinical studies and potential clinical applications.

Our research integrates next-generation sequencing (NGS)-based technologies and bioinformatics

tools to investigate the component, epigenetic, and 3D level changes of enhancers in cancers

(refer toCell, 2014 159: 358–373). We are efficiently combining biochemical, cellular, and animal

model-related studies with different NGS-based assays. Our research program will help the

trainees from both wet and dry lab sides to build up strong expertise and training record in

molecular biology and multi-omics (genomics, transcriptomics, proteomics, epigenomics and

metabolomics).

Positions require a Ph.D. degree (or equivalent) in biochemistry, cell biology, cancer biology,

bioinformatics, or closely related biological sciences. The candidates need to have high motivation

and strong molecular biology background. Any prior experience in patient-derived xenograft (PDX)

models, breast/prostate cancer, and computational analyses will be valued.

San Antonio is one of the fastest growing cities. The UTHSCSA is the largest university of health

science in South Texas and one of four medical schools in the UT System. The affiliated Cancer

Therapy & Research Center (CTRC) is one of the NCI-designated national cancer centers in the state

of Texas. A competitive salary and benefits package will be provided.

To apply:

Please send the application package in one single pdf file including a cover letter briefly describing

your previous experience and your future research interest/plan, curriculum vitae with list of

publications, and contact information of at least three references to the following email. You are also

welcome to send any inquiries or questions you might have.

Contact information:

Dr. Jason Liu

Department of Molecular Medicine

The University of Texas Health Science Center at San Antonio

7703 Floyd Curl Drive

San Antonio, TX, 78229-3900

Email: LiuZ7@uthscsa.edu

Institution Web Site:http://molecularmedicine.uthscsa.edu/index.aspx

"All Postdoctoral appointments are designated as security sensitive positions."

"The University of Texas Health Science Center at San Antonio is an Equal Employment

Opportunity/Affirmative Action Employer including protected veterans and persons with disabilities."

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